The platinum drugs cisplatin, carboplatin, and oxaliplatin are highly found in the clinic and as a result are extensively studied within the laboratory setting. Within this study, we examined the literature and located a substantial quantity of studies (11%-34%) in prominent cancer journals utilizing cisplatin dissolved in DMSO. However, dissolving cisplatin in DMSO for laboratory-based studies leads to ligand displacement and changes towards the structure from the complex. We examined the result of DMSO on platinum complexes, including cisplatin, carboplatin, and oxaliplatin, discovering that DMSO reacted using the complexes, inhibited their cytotoxicity as well as their capability to initiate cell dying. These results render a considerable area of the literature on cisplatin uninterpretable. Raising understanding of this significant trouble in the cancer biology community is crucial, so we make tips about appropriate solvation of platinum drugs for research.